Ole Miss vs. Wake Forest Prediction, Odds, Picks for College Football Week 3

It's time to continue our college football odds series with an Ole Miss-Wake Forest prediction and pick. Find out how to watch Ole Miss-Wake Forest.

The Wake Forest Demon Deacons have a big challenge ahead of them this week – no, not playing Ole Miss, but dealing with a painful setback and trying to overcome it. The Week 2 ACC game between Wake Forest and Virginia was a big moment early in the season for both sides. The winner would take a lot of momentum and confidence from the game, as the coaches believed it could set up a successful season and convince players they had more potential than previously thought. The losing side would pick themselves back up and try to catch up, but the pain of defeat would get in the way of that larger process. Virginia and Wake played a very close and competitive game, and Wake narrowly fell short in the fourth quarter. The Deacs need to find a way to turn the tide, but that just won't be easy. Now Wake has to face a top-10 Ole Miss team while also processing the heartbreaking disappointment of what happened last week against Virginia. This situation will test Wake Forest mentally, emotionally, physically, tactically and in every other way. We'll see how much the Deacs have in the tank against the Rebels, who not only look to make the College Football Playoff this season, but also to make the SEC Championship Game in Atlanta for the very first time in school history. Ole Miss is the only SEC school that played in the SEC West from 1992-2023 and never reached the SEC title game. (Kentucky and Vanderbilt were part of the SEC East for those 32 seasons and never made it to the SEC Championship Game. Ole Miss is the only longtime SEC West program to go 32 games without a win.) The Rebels have a strong incentive to not only play well, but to make history this year.

It's your turn, Wake. This is going to be a tough fight.

Here are the odds for the Ole Miss-Wake Forest college football game, courtesy of FanDuel.

College Football Odds: Ole Miss-Wake Forest Odds

Ole Miss: -22.5 (-110)

Money line: -2000

Wake Forest: +22.5 (-110)

Money line: +980

Over: 63.5 (-115)

Under: 63.5 (-105)

How to watch Ole Miss vs Wake Forest

Time: 6:30 p.m. ET/3:30 p.m. PT

Television: CW Network

Stream: fuboTV (Free Trial)

Why Ole Miss could cover the spread/profit

The Rebels are much better than the Demon Deacons in every way. They are bigger, faster, stronger, more experienced, more skilled and have more game-changing athletes. There's just not much more to say, especially since Wake Forest might be discouraged after the tough loss to Virginia.

Why Wake Forest could cover the spread/profit

It won't be that hard for Wake Forest to put Virginia behind them and focus on this game. The Demon Deacons are hosting a top-10 team. That should get their blood pumping and their juices flowing. Ole Miss has played two small teams at home. Now the Rebels are on the road. The spread is huge. Ole Miss could play poorly in one quarter and that would be enough to keep that spread under the 22.5-point mark.

Final Ole Miss-Wake Forest Prediction and Pick

This game is best enjoyed as a neutral observer rather than betting on it when someone has something on the line. We're leaning towards Ole Miss, but the Rebels could be a little sluggish in their first road game of the year. We'll pass.

Final Ole Miss-Wake Forest prediction and pick: Ole Miss -22.5